What Is GLP-1 and How Does It Help With Weight Loss?
GLP-1 (glucagon-like peptide-1) is a hormone your gut naturally releases after you eat. It signals to your brain that you're full, slows stomach emptying, and helps regulate blood sugar. Certain medications mimic this hormone — and research shows they can lead to significant, sustained weight loss for people who qualify.
GLP-1 (glucagon-like peptide-1) is a hormone your gut naturally releases after you eat. It signals to your brain that you're full, slows stomach emptying, and helps regulate blood sugar. Certain medications mimic this hormone — and research shows they can lead to significant, sustained weight loss for people who qualify.
How GLP-1 medications work
GLP-1 receptor agonists bind to receptors in the brain and digestive system. The result: you feel full sooner, stay full longer, and experience fewer cravings. Clinical trials have shown average weight loss of 15–20% of body weight over 12–18 months in appropriate candidates.
Who may be a candidate?
GLP-1 therapy is generally considered for adults with a BMI of 30 or higher, or 27 or higher with a weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. A licensed provider reviews your full health history to determine if this treatment is right for you.
What about compounded GLP-1?
Compounded versions of GLP-1 medications may be available when FDA-approved options are on shortage or when individualized dosing is needed. Compounded medications are not FDA-approved. A provider and licensed pharmacy must determine if compounding is appropriate for you.
Important safety information
GLP-1 medications are not appropriate for everyone. People with a personal or family history of medullary thyroid cancer, MEN2 syndrome, pancreatitis, or certain other conditions should not use these medications. Always disclose your full medical history to your provider.
This content is educational and does not constitute medical advice.
Quick answers
- How GLP-1 medications work
- GLP-1 receptor agonists bind to receptors in the brain and digestive system. The result: you feel full sooner, stay full longer, and experience fewer cravings. Clinical trials have shown average weight loss of 15–20% of body weight over 12–18 months in appropriate candidates.
- Who may be a candidate?
- GLP-1 therapy is generally considered for adults with a BMI of 30 or higher, or 27 or higher with a weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. A licensed provider reviews your full health history to determine if this treatment is right for you.
- What about compounded GLP-1?
- Compounded versions of GLP-1 medications may be available when FDA-approved options are on shortage or when individualized dosing is needed. Compounded medications are not FDA-approved. A provider and licensed pharmacy must determine if compounding is appropriate for you.
- Important safety information
- GLP-1 medications are not appropriate for everyone. People with a personal or family history of medullary thyroid cancer, MEN2 syndrome, pancreatitis, or certain other conditions should not use these medications. Always disclose your full medical history to your provider. This content is educational and does not constitute medical advice.
Medical disclaimer: This article is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new treatment or making changes to your current care.